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Phytochemical Constituents and Anti-inflammatory Activities of Momordicaaugustisepala Seed and Stem Species Grown in Nigeria

Received: 2 November 2020     Accepted: 17 November 2020     Published: 31 December 2020
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Abstract

Diseases and infections are two of the most notable health challenges that humans are facing today; these have led to different health impairments, death and other economic damages. To combat these menaces, leaf and stem of Momordicaaugustisepala plant have been noted for their medicinal properties. Ethanol extract of Momordicaaugustisepala leaf and stem was investigated for their phytochemical constituents and antimicrobial activities. M. augustisepala leaf (MAL) andstem (MAS) was collected in Ogbomoso. Exactly 500 g of leafand stem was soaked in 4000 mL of ethanol. It was agitated for 1 hour at room temperature (27°C) in ultrasonic sonicator based on their polarity. The extract was then decanted, combined, filtered and concentrated using Rotary Evaporator at 40°C. The Fourier transforms infrared (FT-IR) spectra and ultraviolet-visible (UV-VIS) spectrophotometer was obtained on a Perkin Elmer Spectrum and Varian Cary ultraviolet-visible. Results of the phytochemical analysis of the Momordicaaugustisepala leaf and stem showed the presence of Alkaloids, Glycosides, Flavonoids, Terpenoids, Tannins, Saponins, Phenols, Steroids and Anthraquinones, and Momordicaaugustisepala stem revealed, Alkaloids, flavonoids, Anthraquinones, Glycoside, Steroids, terpenoids, Tannins, Saponins and Phenols, while reducing sugar and phlobatanins were absent. Maximum inhibition protein denaturation of 86.6% and 89.3%was observed at 500μg/ml for anti-inflammatory activities. As compared to Aspirin standard anti-inflammation drug which gave 85.9% at the same concentration. The results revealed that both seed and stem of M. augustisepala have potential for antimicrobial and anti- inflammatory activities which may be due to the presence of plant secondary metabolites.

Published in Modern Chemistry (Volume 8, Issue 4)
DOI 10.11648/j.mc.20200804.12
Page(s) 54-63
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Phytochemical Constituents, Antimicrobial Activity, Anti-inflammatory, Momordicaaugustisepala, Ethanol Extract

References
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    Ezekiel Gbadebo Adeyeni, Ezekiel Temidayo Ayodele, Taofik Adewale Adedosu, Olusola Nathaniel Majolagbe, Ruth Adeola Adeyeni. (2020). Phytochemical Constituents and Anti-inflammatory Activities of Momordicaaugustisepala Seed and Stem Species Grown in Nigeria. Modern Chemistry, 8(4), 54-63. https://doi.org/10.11648/j.mc.20200804.12

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    ACS Style

    Ezekiel Gbadebo Adeyeni; Ezekiel Temidayo Ayodele; Taofik Adewale Adedosu; Olusola Nathaniel Majolagbe; Ruth Adeola Adeyeni. Phytochemical Constituents and Anti-inflammatory Activities of Momordicaaugustisepala Seed and Stem Species Grown in Nigeria. Mod. Chem. 2020, 8(4), 54-63. doi: 10.11648/j.mc.20200804.12

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    AMA Style

    Ezekiel Gbadebo Adeyeni, Ezekiel Temidayo Ayodele, Taofik Adewale Adedosu, Olusola Nathaniel Majolagbe, Ruth Adeola Adeyeni. Phytochemical Constituents and Anti-inflammatory Activities of Momordicaaugustisepala Seed and Stem Species Grown in Nigeria. Mod Chem. 2020;8(4):54-63. doi: 10.11648/j.mc.20200804.12

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  • @article{10.11648/j.mc.20200804.12,
      author = {Ezekiel Gbadebo Adeyeni and Ezekiel Temidayo Ayodele and Taofik Adewale Adedosu and Olusola Nathaniel Majolagbe and Ruth Adeola Adeyeni},
      title = {Phytochemical Constituents and Anti-inflammatory Activities of Momordicaaugustisepala Seed and Stem Species Grown in Nigeria},
      journal = {Modern Chemistry},
      volume = {8},
      number = {4},
      pages = {54-63},
      doi = {10.11648/j.mc.20200804.12},
      url = {https://doi.org/10.11648/j.mc.20200804.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.mc.20200804.12},
      abstract = {Diseases and infections are two of the most notable health challenges that humans are facing today; these have led to different health impairments, death and other economic damages. To combat these menaces, leaf and stem of Momordicaaugustisepala plant have been noted for their medicinal properties. Ethanol extract of Momordicaaugustisepala leaf and stem was investigated for their phytochemical constituents and antimicrobial activities. M. augustisepala leaf (MAL) andstem (MAS) was collected in Ogbomoso. Exactly 500 g of leafand stem was soaked in 4000 mL of ethanol. It was agitated for 1 hour at room temperature (27°C) in ultrasonic sonicator based on their polarity. The extract was then decanted, combined, filtered and concentrated using Rotary Evaporator at 40°C. The Fourier transforms infrared (FT-IR) spectra and ultraviolet-visible (UV-VIS) spectrophotometer was obtained on a Perkin Elmer Spectrum and Varian Cary ultraviolet-visible. Results of the phytochemical analysis of the Momordicaaugustisepala leaf and stem showed the presence of Alkaloids, Glycosides, Flavonoids, Terpenoids, Tannins, Saponins, Phenols, Steroids and Anthraquinones, and Momordicaaugustisepala stem revealed, Alkaloids, flavonoids, Anthraquinones, Glycoside, Steroids, terpenoids, Tannins, Saponins and Phenols, while reducing sugar and phlobatanins were absent. Maximum inhibition protein denaturation of 86.6% and 89.3%was observed at 500μg/ml for anti-inflammatory activities. As compared to Aspirin standard anti-inflammation drug which gave 85.9% at the same concentration. The results revealed that both seed and stem of M. augustisepala have potential for antimicrobial and anti- inflammatory activities which may be due to the presence of plant secondary metabolites.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Phytochemical Constituents and Anti-inflammatory Activities of Momordicaaugustisepala Seed and Stem Species Grown in Nigeria
    AU  - Ezekiel Gbadebo Adeyeni
    AU  - Ezekiel Temidayo Ayodele
    AU  - Taofik Adewale Adedosu
    AU  - Olusola Nathaniel Majolagbe
    AU  - Ruth Adeola Adeyeni
    Y1  - 2020/12/31
    PY  - 2020
    N1  - https://doi.org/10.11648/j.mc.20200804.12
    DO  - 10.11648/j.mc.20200804.12
    T2  - Modern Chemistry
    JF  - Modern Chemistry
    JO  - Modern Chemistry
    SP  - 54
    EP  - 63
    PB  - Science Publishing Group
    SN  - 2329-180X
    UR  - https://doi.org/10.11648/j.mc.20200804.12
    AB  - Diseases and infections are two of the most notable health challenges that humans are facing today; these have led to different health impairments, death and other economic damages. To combat these menaces, leaf and stem of Momordicaaugustisepala plant have been noted for their medicinal properties. Ethanol extract of Momordicaaugustisepala leaf and stem was investigated for their phytochemical constituents and antimicrobial activities. M. augustisepala leaf (MAL) andstem (MAS) was collected in Ogbomoso. Exactly 500 g of leafand stem was soaked in 4000 mL of ethanol. It was agitated for 1 hour at room temperature (27°C) in ultrasonic sonicator based on their polarity. The extract was then decanted, combined, filtered and concentrated using Rotary Evaporator at 40°C. The Fourier transforms infrared (FT-IR) spectra and ultraviolet-visible (UV-VIS) spectrophotometer was obtained on a Perkin Elmer Spectrum and Varian Cary ultraviolet-visible. Results of the phytochemical analysis of the Momordicaaugustisepala leaf and stem showed the presence of Alkaloids, Glycosides, Flavonoids, Terpenoids, Tannins, Saponins, Phenols, Steroids and Anthraquinones, and Momordicaaugustisepala stem revealed, Alkaloids, flavonoids, Anthraquinones, Glycoside, Steroids, terpenoids, Tannins, Saponins and Phenols, while reducing sugar and phlobatanins were absent. Maximum inhibition protein denaturation of 86.6% and 89.3%was observed at 500μg/ml for anti-inflammatory activities. As compared to Aspirin standard anti-inflammation drug which gave 85.9% at the same concentration. The results revealed that both seed and stem of M. augustisepala have potential for antimicrobial and anti- inflammatory activities which may be due to the presence of plant secondary metabolites.
    VL  - 8
    IS  - 4
    ER  - 

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Author Information
  • Department of Pure and Applied Chemistry, LadokeAkintola University of Technology, Ogbomoso, Nigeria

  • Department of Pure and Applied Chemistry, LadokeAkintola University of Technology, Ogbomoso, Nigeria

  • Department of Pure and Applied Chemistry, LadokeAkintola University of Technology, Ogbomoso, Nigeria

  • Department of Pure and Applied Biology, LadokeAkintola University of Technology, Ogbomoso, Nigeria

  • Department of Pure and Applied Chemistry, LadokeAkintola University of Technology, Ogbomoso, Nigeria

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