Review Article
Coffee's Health Benefits for Human Diet
Issue:
Volume 12, Issue 4, December 2024
Pages:
75-81
Received:
17 October 2024
Accepted:
6 November 2024
Published:
26 November 2024
Abstract: Coffee is the most popular beverage in the world and the most consumed caffeinated beverage after water and tea. It contains a combination of several chemical components that, with the health benefits, most consumers start the day with at least one cup of coffee after eating and end the working day with coffee. It is considered an important part of modern-day life because it has an alarming effect on the human brain. In contrast, different groups report. They face unequal health risks and are therefore reluctant to drink coffee, suggesting individual differences in coffee intolerance. The purpose of this study was to briefly summarize the health benefits and risks of coffee consumption. Most informative reports suggest that long-term consumption of coffee and decaffeinated coffee can reduce the risk of many diseases. Among them, it is used to improve our physical performance, burn fat, reduce the risk of stroke, liver, prostate and colorectal cancer by 20%, the risk of Parkinson's disease by 25%. the risk of dementia and protect our mind, brighten our mood, help fight depression and minimize the risk of suicide by 50%. In addition, coffee drinkers have a lower risk of heart disease, with highly integrated DNA. It has also been reported that coffee consumption naturally lengthens sleep latency, decreases total sleep duration and efficiency, and worsens putative sleep functions. However, from the positive health perspective of coffee consumption, a recent study reveals that coffee consumption does not always provide protective benefits, since excessive consumption is associated with a negative impact or risk to our health. Some negative effects of coffee consumption on our health: reduces appetite, affects pregnant women, people with cholesterol, causes insomnia and restlessness, breast tissue cysts in women, digestive disorders related to incontinence and risk of headache In addition, it reduces the likelihood of fertility in women and men, causes allergies and abortions, violent heart contractions, anxiety, depression and the need for anti-anxiety drugs, inhibits the production of collagen in human skin, improves the hearing loss. it does not help with prolonged sleep deprivation, it interferes with ossification and may even lead to an increased risk of bone fracture. Finally, more recent studies have reported that the consumption of coffee is beneficial for our health when it is optimal, about four glasses on average. Further research will be crucial to clarify the health benefits and risks of coffee consumption.
Abstract: Coffee is the most popular beverage in the world and the most consumed caffeinated beverage after water and tea. It contains a combination of several chemical components that, with the health benefits, most consumers start the day with at least one cup of coffee after eating and end the working day with coffee. It is considered an important part of...
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Research Article
A Method for Determination of Hydrocarbon and Nitrogenous Biochemical Oxygen Demands in Natural Waters by Manometric Method
Suren Sargsyan*
Issue:
Volume 12, Issue 4, December 2024
Pages:
82-88
Received:
5 November 2024
Accepted:
18 November 2024
Published:
29 November 2024
Abstract: The aim of the work was the simultaneous determination of hydrocarbon biochemical oxygen demand - cBOD and nBOD (nitrogen) in the same water sample without using a nitrification inhibitor by the manometric method. Daily measurements of cBOD are determined by recording the pressure drop resulting from the absorption of carbon dioxide released by the oxidation of hydrocarbon organic matter by microorganisms with KOH (potassium hydroxide). Here, the processes of oxidation of mineral substances in water and especially the developing nitrification processes, which absorb oxygen dissolved in water and cause an additional pressure drop in the vessel, are a disturbing factor, for the measurement of which, in the daily 24-hour cycle of registrations, it is recommended to close the absorption hole of the vial with KOH for 8 hours. The 24-hour nBOD and cBOD results are calculated from the result of the pressure drop in these 8 hours. In the paper, in the form of a table, the detailed form of calculation of the recorded results of BODs at two pH-s of a natural water sample within 1-20 days is given. The possibility of anthropogenic impact assessment using this method is shown on the example of natural water. It is concluded that with the proposed method of measuring BODs records the complete and separate results of cBOD are recorded under conditions of developing nitrification in water. All information from both nitrification and BOD-full is recorded simultaneously, which gives a complete picture of the overall oxygen balance in the water. The proposed method is practically applicable and fully comparable with the results obtained by the standard manometric method.
Abstract: The aim of the work was the simultaneous determination of hydrocarbon biochemical oxygen demand - cBOD and nBOD (nitrogen) in the same water sample without using a nitrification inhibitor by the manometric method. Daily measurements of cBOD are determined by recording the pressure drop resulting from the absorption of carbon dioxide released by the...
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Review Article
The Role of PDZ in Cerebral Ischemia
Issue:
Volume 12, Issue 4, December 2024
Pages:
89-98
Received:
6 August 2024
Accepted:
2 September 2024
Published:
10 December 2024
Abstract: Cerebral ischemia is a widespread disease and a leading cause of death and disability worldwide. Its complex origins and the mysterious mechanisms behind its development make it a formidable adversary in the field of medicine. PDZ proteins are part of the human proteome with multiple functions and have been identified as key mediators of cell signaling and synaptic transmission. Their interactions with PDZ-binding proteins underlie their role in the pathogenesis of a variety of diseases. In this paper, PDZ domains have been extensively studied, exploring their structural properties and functional roles in cells. This review highlights the importance of these domains in signal transduction pathways, which are essential for the normal function of the nervous system. It also highlights emerging evidence linking PDZ proteins to the regulation of angiogenesis in cerebrovascular diseases, a key process in the development of ischemic disease. In addition, we further discuss the potential of PDZ proteins in neuronal regeneration, an area that is expected to play a role in stroke development and subsequent rehabilitation. This review also discusses the link between PDZ proteins and excitatory synaptic transmission, further exploring the mechanisms involved in excitatory toxicity. By analyzing the complex relationship between PDZ proteins and their binding partner, this paper aims to reveal the molecular basis of cerebral ischemia. This suggests that a deeper understanding of these interactions could pave the way for innovative therapeutic interventions for stroke management. The review concludes by advocating continued research into PDZ proteins, recognizing their potential as building blocks for the development of new treatment and prevention strategies for stroke and related disorders.
Abstract: Cerebral ischemia is a widespread disease and a leading cause of death and disability worldwide. Its complex origins and the mysterious mechanisms behind its development make it a formidable adversary in the field of medicine. PDZ proteins are part of the human proteome with multiple functions and have been identified as key mediators of cell signa...
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