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Metal Complexes of Schiff Bases Derived from 2-Thiophenecarboxaldehyde and Mono/Diamine as the Antibacterial Agents

Received: 22 April 2014     Accepted: 13 May 2014     Published: 30 May 2014
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Abstract

The Schiff bases, formed by condensation of 2-thiophenecarboxaldehyde with 2-aminothiophenol (LH) and propane-1,2-diamine (L1), and their complexes of Ni(II), Cu(II), Zn(II) and Cd(II) have been prepared and characterized by elemental analysis, and magnetic and spectroscopic measurements. Infrared and NMR spectra of the complexes agree with the coordination to the central metal atom through the nitrogen of the azomethine (-HC=N-) group and the sulfur atom of the thiophene ring. Magnetic susceptibility data coupled with electronic suggest octahedral structure for the complexes. Conductance measurements suggest the non-electrolytic nature of the complexes. Stoichiometry of complexes has been suggested as [M(L)2] and [ML1Cl2]. The Schiff base and its metal chelates have been screened for their in vitro antibacterial activity against four human pathogenic bacteria. Ligands show moderately whereas some of metal chelates show highly antibacterial activity against them.

Published in Modern Chemistry (Volume 2, Issue 2)
DOI 10.11648/j.mc.20140202.11
Page(s) 6-14
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Metal Complexes, Schiff Bases, 2-Thiophenecarboxaldehyde, 2-Aminothiophenol, Propane-1, 2-Diamine, Antibacterial Activity

References
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[5] M Montazerozohori; M Sedighipoor; S Joohari. Int. J. Electrochem. Sci., 2012, 7, 77– 88.
[6] DA Chowdhury; MN Uddin; F Hoque. Chiang Mai J. Sci. 2010, 37(3), 443-450.
[7] DA Chowdhury; MN Uddin; MAH Sarker; Chiang Mai J. Sci. 2008, 35(3), 483-494.
[8] DA Chowdhury; MN Uddin; GK Chowdhury. The Chitt. Uni. J. of Sci. 2006, 30(1), 85-88.
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[10] C SṕInu; M Pleniceanu; C Tigae. Turk J Chem, 2008, 32, 487– 493.
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  • APA Style

    Mohammad Nasir Uddin, Didarul Alam Chowdhury, Md. Moniruzzman Rony, Md. Ershad Halim. (2014). Metal Complexes of Schiff Bases Derived from 2-Thiophenecarboxaldehyde and Mono/Diamine as the Antibacterial Agents. Modern Chemistry, 2(2), 6-14. https://doi.org/10.11648/j.mc.20140202.11

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    ACS Style

    Mohammad Nasir Uddin; Didarul Alam Chowdhury; Md. Moniruzzman Rony; Md. Ershad Halim. Metal Complexes of Schiff Bases Derived from 2-Thiophenecarboxaldehyde and Mono/Diamine as the Antibacterial Agents. Mod. Chem. 2014, 2(2), 6-14. doi: 10.11648/j.mc.20140202.11

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    AMA Style

    Mohammad Nasir Uddin, Didarul Alam Chowdhury, Md. Moniruzzman Rony, Md. Ershad Halim. Metal Complexes of Schiff Bases Derived from 2-Thiophenecarboxaldehyde and Mono/Diamine as the Antibacterial Agents. Mod Chem. 2014;2(2):6-14. doi: 10.11648/j.mc.20140202.11

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  • @article{10.11648/j.mc.20140202.11,
      author = {Mohammad Nasir Uddin and Didarul Alam Chowdhury and Md. Moniruzzman Rony and Md. Ershad Halim},
      title = {Metal Complexes of Schiff Bases Derived from 2-Thiophenecarboxaldehyde and Mono/Diamine as the Antibacterial Agents},
      journal = {Modern Chemistry},
      volume = {2},
      number = {2},
      pages = {6-14},
      doi = {10.11648/j.mc.20140202.11},
      url = {https://doi.org/10.11648/j.mc.20140202.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.mc.20140202.11},
      abstract = {The Schiff bases, formed by condensation of 2-thiophenecarboxaldehyde with 2-aminothiophenol (LH) and propane-1,2-diamine (L1), and their complexes of Ni(II), Cu(II), Zn(II) and Cd(II) have been prepared and characterized by elemental analysis, and magnetic and spectroscopic measurements. Infrared and NMR spectra of the complexes agree with the coordination to the central metal atom through the nitrogen of the azomethine (-HC=N-) group and the sulfur atom of the thiophene ring. Magnetic susceptibility data coupled with electronic suggest octahedral structure for the complexes. Conductance measurements suggest the non-electrolytic nature of the complexes. Stoichiometry of complexes has been suggested as [M(L)2] and [ML1Cl2]. The Schiff base and its metal chelates have been screened for their in vitro antibacterial activity against four human pathogenic bacteria. Ligands show moderately whereas some of metal chelates show highly antibacterial activity against them.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Metal Complexes of Schiff Bases Derived from 2-Thiophenecarboxaldehyde and Mono/Diamine as the Antibacterial Agents
    AU  - Mohammad Nasir Uddin
    AU  - Didarul Alam Chowdhury
    AU  - Md. Moniruzzman Rony
    AU  - Md. Ershad Halim
    Y1  - 2014/05/30
    PY  - 2014
    N1  - https://doi.org/10.11648/j.mc.20140202.11
    DO  - 10.11648/j.mc.20140202.11
    T2  - Modern Chemistry
    JF  - Modern Chemistry
    JO  - Modern Chemistry
    SP  - 6
    EP  - 14
    PB  - Science Publishing Group
    SN  - 2329-180X
    UR  - https://doi.org/10.11648/j.mc.20140202.11
    AB  - The Schiff bases, formed by condensation of 2-thiophenecarboxaldehyde with 2-aminothiophenol (LH) and propane-1,2-diamine (L1), and their complexes of Ni(II), Cu(II), Zn(II) and Cd(II) have been prepared and characterized by elemental analysis, and magnetic and spectroscopic measurements. Infrared and NMR spectra of the complexes agree with the coordination to the central metal atom through the nitrogen of the azomethine (-HC=N-) group and the sulfur atom of the thiophene ring. Magnetic susceptibility data coupled with electronic suggest octahedral structure for the complexes. Conductance measurements suggest the non-electrolytic nature of the complexes. Stoichiometry of complexes has been suggested as [M(L)2] and [ML1Cl2]. The Schiff base and its metal chelates have been screened for their in vitro antibacterial activity against four human pathogenic bacteria. Ligands show moderately whereas some of metal chelates show highly antibacterial activity against them.
    VL  - 2
    IS  - 2
    ER  - 

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Author Information
  • Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh

  • Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh

  • Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh

  • Department of Chemistry, University of Dhaka, Dhaka, Bangladesh

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